NCT02051296

Minocycline to Reduce Pain After Carpal Tunnel Release

A Trial of Minocycline for Pain After Carpal Tunnel and Trigger Release

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 131 (actual)
• Sponsor: VA Palo Alto Health Care System · Federal
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The investigators are looking at whether peri-operative minocycline will reduce the duration of pain after minor hand surgery: carpal tunnel release and trigger finger release. The investigators' hypothesis is that minocycline will reduce post-operative pain.

Detailed description

This is a double blinded randomized controlled trial. Patients are given 100mg of minocycline 2 hours prior to their procedure and then 100mg two times a day for 5 days. The subjects are then contacted daily to check their level of pain. The investigators' outcome of interest is time to pain resolution. The investigators will perform a futility analysis to assess if a larger trial would be a reasonable next step after this pilot study.

Conditions

• Chronic Pain
• Post-operative Pain

Interventions

Type	Name	Description
DRUG	Minocycline	RCT blinded placebo trial
DRUG	placebo	RCT blinded placebo trial

Timeline

• Start date: 2012-01-01
• Primary completion: 2014-04-01
• Completion: 2014-04-01
• First posted: 2014-01-31
• Last updated: 2018-06-11
• Results posted: 2018-06-11

Locations

1 site across 1 country: United States