NCT02050997

Plasma Biomarkers P-DAC, V1

Identification of Predictive Plasma Biomarkers in Pancreatic Ductal Adenocarcinoma (PDAC Plasma Biomarker Study)

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 169 (actual)
• Sponsor: Cancer Trials Ireland · Network
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is an exploratory, translational, non-interventional and multi-centre clinical study. The aim of the study is to identify predictive plasma biomarkers of response to chemotherapy in PDAC.

Detailed description

This study will involve two cohort groups, all patients involved will have PDAC. Cohort A: Target is 80 resectable PDAC patients who will receive standard treatment of chemotherapy +/- radiotherapy Cohort B: * Cohort B1 = Target is 80 unresectable locally advanced PDAC patients who will receive standard treatment of chemotherapy +/- radiotherapy. * Cohort B2 = Target is metastatic PDAC patients who will receive standard treatment of chemotherapy +/- radiotherapy. Control patients: Target is 50, with acute pancreatitis admitted to hospital for observation/treatment. Blood samples will be taken at the following time points: * prior to resection, whenever feasible for cohort A * prior to CT, for both cohort A and B * during CT, for both cohort A and B * follow-up, approximately every 3 to 6 months for two years for cohort A

Conditions

• Pancreatic Ductal Adenocarcinoma

Timeline

• Start date: 2014-05-26
• Primary completion: 2021-12-01
• Completion: 2021-12-01
• First posted: 2014-01-31
• Last updated: 2025-07-08

Locations

9 sites across 1 country: Ireland