NCT02050399

Cardiovascular Oscillations in Coronary Patients With and Without Type 2 Diabetes

Cardiovascular Oscillations at Rest and During Isometric Exercise in Coronary Patients With and Without Type 2 Diabetes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Universidade Federal de Sao Carlos · Academic / Other
• Sex: Male
• Age: 45 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Coronary artery disease (CAD) and diabetes mellitus (DM) may promote alterations in heart responses during exercise or postural maneuver. Thus, the purpose of this study is to observe the influence of different postures (supine, seated and standing) and different percentages (15, 30, 45 and 60%) of the maximum voluntary contraction (MVC) of handgrip in the responses of heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), cardiac output (CO), stroke volume (SV) and peripheral vascular resistance (PVR) in coronary patients with and without type 2 diabetes.

Conditions

• Coronary Artery Disease
• Diabetes Mellitus, Type 2

Interventions

Type	Name	Description
OTHER	Isometric exercise	The isometric protocol (handgrip) will be performed into 4 percentages of MVC (15, 30, 45 and 60%) to exhaustion in 3 postures (supine, seated and standing position). The percentages and the postures will be randomized. In the first day of exercise protocol the subjects will be at rest during 10 minutes and will perform 3 MVC during 5 seconds, with 5 minutes of recovery. The higher value of MVC will be used to prescribe the percentages. The subjects will perform two contractions until exhaustion in one posture in each day.

Timeline

• Start date: 2013-08-01
• Primary completion: 2015-12-01
• Completion: 2016-03-01
• First posted: 2014-01-30
• Last updated: 2018-01-26

Locations

1 site across 1 country: Brazil