NCT02046941

Brain Biomarkers of Response to Treatment for Apraxia of Speech

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: VA Office of Research and Development · Federal
• Sex: All
• Age: 40 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The study will use MRI brain imaging to identify brain changes associated in stroke patients after they receive speech-language treatment for their speech difficulties.

Detailed description

The goals of the current study are to identify grey and white matter regions that are predictive of speech treatment response and measure neural plasticity in response to speech treatment, using state-of-the-art neuroimaging and statistical processing techniques in a group of well-characterized left hemisphere patients meeting strict inclusionary criteria. Specifically, the investigators will use voxel-based lesion symptom mapping to identify lesion sites most predictive of a positive response to speech treatment and advanced diffusion imaging techniques to map changes in the integrity of white matter tracts from pre- to post-treatment.

Conditions

• Aphasia
• Stroke

Interventions

Type	Name	Description
BEHAVIORAL	Speech Production Treatment	This treatment employs a response-contingent hierarchy made up of verbal modeling/repetition, graphic cueing, integral stimulation, and articulatory placement instruction.

Timeline

• Start date: 2014-03-01
• Primary completion: 2018-01-08
• Completion: 2018-06-30
• First posted: 2014-01-28
• Last updated: 2019-08-28
• Results posted: 2019-08-28

Locations

1 site across 1 country: United States