NCT02042924

Pilot Study of Multi-Modality Imaging in Patients With Hematologic Malignancies

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 2 (actual)
• Sponsor: Masonic Cancer Center, University of Minnesota · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a pilot sub-study of patients receiving myeloablative transplant using total body irradiation (TBI) or total marrow irradiation (TMI) in their preparative regimen. The objective of this stub-study is to estimate the heterogeneity in cellular proliferation (FLT-PET uptake) as well the heterogeneity in marrow composition distribution (measured using whole body water-fat MRI) using positron emission tomography imaging. This will be used to design future trials as well as to determine the feasibility of PET and MRI imaging.

Conditions

• Hematologic Malignancy

Interventions

Type	Name	Description
RADIATION	FLT PET/CT	Functional marrow imaging using the FLT PET/CT will be performed prior to preparative for HSCT and approximately 3 months post-transplant (Day 100 +/- 5 days).
DEVICE	MRI	MRI imaging will be performed prior to preparative for HSCT and approximately 3 months post-transplant (Day 100 +/- 5 days).

Timeline

• Start date: 2014-01-01
• Primary completion: 2015-11-01
• Completion: 2015-11-01
• First posted: 2014-01-23
• Last updated: 2017-12-05
• Results posted: 2017-06-09

Locations

1 site across 1 country: United States