Trials / Completed
CompletedNCT02042560
Study of Immune Thrombocytopenia Pathogenesis:
Study of Immune Thrombocytopenia Pathogenesis: a Multicenter, Open and Controlled Study.
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 89 (actual)
- Sponsor
- Centre Hospitalier Universitaire Dijon · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a low platelet count responsible for bleedings. The disease is mostly mediated by antiplatelet antibodies produced by specific B cells. However, T cells are also involved but their role is not completely understood. The aim of this study is to determine the implication of T cells in the pathogenesis of ITP, notably regulatory T cells (Treg, CD4+CD25highFoxp3+), cytotoxic T cells (CD3+CD8+) and T follicular helper cells (TFH, CD3+CD4+CXCR5+PD-1+ICOS+), in blood and in the spleen of primary ITP patients, compared to healthy controls.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Blood samples | |
| OTHER | Spleen samples |
Timeline
- Start date
- 2011-05-04
- Primary completion
- 2015-03-12
- Completion
- 2015-03-12
- First posted
- 2014-01-23
- Last updated
- 2018-03-15
Locations
3 sites across 1 country: France
Source: ClinicalTrials.gov record NCT02042560. Inclusion in this directory is not an endorsement.