NCT02038712

fMRI and Ghlrein in Obesity and Binge Eating Disorder

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 93 (actual)
• Sponsor: New York Obesity and Nutrition Research Center · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Binge Eating Disorder (BED) may be associated with he development of obesity. However, the pathogenesis of BED is currently unclear, thus making the development of treatment and prevention strategies for BED difficult. Differences in the mechanisms regulating food intake may go some way to reveal potential mechanisms for BED.The purpose of this study is to investigate the responses of key gut-derived hormones that are associated with the regulation of food intake and functional brain activity to food cues using fMRI in BED patients and weight matched controls.

Detailed description

Participants will attend the laboratory on two separate occasions following an overnight fast. Following baseline measures they will be provided wither with a 600mL (600kcal) liquid meal (Fed condition) or a volume matched amount of plain water (Fasted condition) to consume within 15 min in a randomized crossover design. Blood samples will be collected for during the subsequent 120min to measure the glucose, insulin and gut hormone responses, and subjective appetite ratings will be collected. 1500mg of acetaminophen will be added to each of the test drinks so that the appearance in the blood can be used as a proxy measure of gastric emptying. Participants will then undergo a 45min brain scan to assess the responses to visual and auditory food cues.

Conditions

• Obesity
• Binge Eating Disorder

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Fed Condition	Subjects will consume a 600mL 600kcal liquid test meal
DIETARY_SUPPLEMENT	Fasted condition	Subjects will consume 600mL plain water.
PROCEDURE	Blood samples	Blood samples will be collected at -15, 0, 10, 30, 60, 90, 120 min
BEHAVIORAL	Subjective appetite ratings	Appetite ratings will be collected at -15, 0, 10, 30, 60, 90, 120 min.
PROCEDURE	fMRI scan	Blood Oxygen Dependent (BOLD) signal response to pictures and words of food and non-food items will be measured using functional magnetic resonance imaging (fMRI).

Timeline

• Start date: 2006-06-01
• Primary completion: 2008-12-01
• Completion: 2013-09-01
• First posted: 2014-01-16
• Last updated: 2014-01-16