NCT02038335

HIV-Target Cell Response in Women Initiating Various Contraceptive Methods in High HIV-Incidence Areas: Zim CHIC

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 451 (actual)
• Sponsor: University of Pittsburgh · Academic / Other
• Sex: Female
• Age: 18 Years – 34 Years
• Healthy volunteers: Not accepted

Summary

This study is being done to understand if using birth control causes changes in the immune cells within the reproductive tract of healthy women. Immune cells are important because they help prevent infections from starting and help fight infections that have started. Immune cells are also the type of cells that HIV (human immunodeficiency virus) infects so understanding more about them will help to better understand how to prevent the spread of HIV. Immune cells will be studied from the reproductive tract of women who want to start using one of the following contraceptives: Depo-Provera (DMPA), NET-EN, MPA/E2 (Cyclofem®), the levonorgestrel subdermal implant (Jadelle® ), the etonogestrel subdermal implant (Implanon® or Nexplanon® ) and the copper IUD.

Conditions

• Contraception
• HIV
• Immune Cells (Mucosal and Systemic)
• Microbiota

Interventions

Type	Name	Description
DRUG	DMPA	Depot medroxyprogesterone acetate
DRUG	NET-EN	Norethisterone enantate
DRUG	MPA/E2	Medroxyprogesterone acetate and estradiol cypionate
DEVICE	LNG-I	Levonorgestrel subdermal implant
DEVICE	ENG-I	Etonogestrel subdermal implant
DEVICE	Cu-IUD	Copper IUD

Timeline

• Start date: 2014-02-01
• Primary completion: 2016-06-01
• Completion: 2020-12-01
• First posted: 2014-01-16
• Last updated: 2020-12-03

Locations

1 site across 1 country: Zimbabwe