NCT02036242

Sole Local Anesthetic Versus Opioid Plus Local Anesthesia in Epidural Labor Analgesia

Sole Epidural Local Anesthetic Versus Opioid Plus Local Anesthetic in Epidural Labor Pain Control

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 500 (actual)
• Sponsor: Nanjing Medical University · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

It is common for obstetric anesthesia using opioid supplement to local anesthetics for epidural labor pain control. Given the low doses of these epidural drugs, we never doubt the necessity of the supplement of opioid to lacal anesthetics during this process based on the concept that opioid addition can enhance and prolong the analgesic effect of local anesthetics. However, we unavoidably encounter many opioid-associated side effects during the labor delivery. In addition, usage of opioid increase the medical cost for each patient. We herein hypothesized that in the context of obstetric anesthesia, sole local anesthetics can produce as the same analgsic effect as opioid plus local anesthetics given for epidural labor pain control.

Conditions

• Pain

Interventions

Type	Name	Description
DRUG	Sole local anesthetic	0.125% ropivacaine 10-15 ml every 1h during labor delivery
DRUG	Sufentanil (Opioid plus local anesthetic)	Sufentanil combined with 0.125% ropivacaine, 10-15 ml every 1h during labor delivery
DRUG	Ropivacaine

Timeline

• Start date: 2013-09-01
• Primary completion: 2014-02-01
• Completion: 2014-02-01
• First posted: 2014-01-14
• Last updated: 2014-02-04

Locations

1 site across 1 country: China