NCT02034526

Reducing Atrial Pacing Rate to Reduce Atrial Fibrillation in Patients With Sick Sinus Syndrome.

A Randomised Controlled Trial of Reducing Atrial Pacing Rate to Reduce Atrial Fibrillation in Patients With Sick Sinus Syndrome and Dual Chamber Pacemaker.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 540 (actual)
• Sponsor: Aarhus University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Atrial fibrillation (AF) is prevalent in patients with sick sinus syndrome (SSS) and associated with an increased risk of stroke and death. Within the first two years after pacemaker implantation almost half of the patients are diagnosed with AF. Studies have indicated that an increased amount of stimulation from the pacemaker in the atria is associated with an increased amount of AF. The aim of the present study is to test the hypothesis that a reduction of stimulation from the pacemaker in the atria, and reducing the minimal heart rate, increases the time to AF.

Conditions

• Sinus Node Disease
• Atrial Fibrillation

Interventions

Type	Name	Description
DEVICE	DDDR-60	DDDR, lower pacing rate 60 bpm, RR activated (low-moderate)
DEVICE	DDD-40	DDD, lower pacing rate 40 bpm, RR function off

Timeline

• Start date: 2014-05-01
• Primary completion: 2023-03-31
• Completion: 2023-03-31
• First posted: 2014-01-13
• Last updated: 2024-02-08

Locations

1 site across 1 country: Denmark