NCT02032654

Duration of ANtibiotic Therapy for CEllulitis

Duration of Antibiotic Therapy for Cellulitis (DANCE): a Randomized Controlled Trial Comparing 6 to 12 Days of Antibiotic Therapy for Patients Hospitalized With Cellulitis

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 151 (actual)
• Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Cellulitis is among the most common infections leading to hospitalization, yet the optimal duration of therapy remains ill defined. Pragmatically, Dutch guidelines advise 10-14 days of antibiotics, which is the current standard of care. Recently it has been shown that antibiotic treatment for pneumonia and urinary tract infections can safely and significantly be shortened. Importantly, in an outpatient setting, treatment of uncomplicated cellulitis with 5 days of antibiotics was as effective as 10 days. We hypothesize that there is no difference in outcomes when patients hospitalized with cellulitis are treated with either a short-course (6 days) or standard-course (12 days) of antibiotics.

Conditions

• Cellulitis
• Erysipelas

Interventions

Type	Name	Description
DRUG	Flucloxacillin
DRUG	Placebo (for flucloxacillin)	Sugar capsule manufactured to mimic flucloxacillin 500mg capsules

Timeline

• Start date: 2014-08-26
• Primary completion: 2017-07-24
• Completion: 2017-09-25
• First posted: 2014-01-10
• Last updated: 2017-10-10

Locations

11 sites across 1 country: Netherlands