NCT02031016

Remifentanil vs Fentanyl During Cardiac Surgery and Chronic Thoracic Pain

A Randomised Clinical Trial Evaluating the Effect of Remifentanil vs Fentanyl During Cardiac Surgery on the Incidence of Chronic Thoracic Pain

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 126 (actual)
• Sponsor: St. Antonius Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

This study will investigate the influence of intra-operative use of remifentanil versus fentanyl on the percentage of patients with chronic thoracic after cardiac surgery via sternotomy. Secondary quantitative sensory testing is performed to determine thermal and electrical detection and pain threshold and the difference in pain variability scoring. Postoperative pain scores, analgesic use, genetic variances and costs are measured.

Conditions

• Chronic Pain
• Sternotomy
• Remifentanil
• Fentanyl

Interventions

Type	Name	Description
DRUG	Fentanyl	fentanyl bolus injections on an "as needed" base, NEXT TO the fentanyl bolus injections on predetermined times; before incision, at sternotomy, at aorta canulation and at opening of the pericardium.
DRUG	Remifentanil	starting with 0.15 ug/IBW(kg)/min, next to fentanyl bolus injections (200-500 ug) on predetermined times; before incision, at sternotomy, at aorta canulation and at opening of the pericardium.
DRUG	Fentanyl	fentanyl bolus injections on predetermined times; before incision, at sternotomy, at aorta canulation and at opening of the pericardium.

Timeline

• Start date: 2014-02-01
• Primary completion: 2016-04-01
• Completion: 2016-04-01
• First posted: 2014-01-09
• Last updated: 2016-10-18

Locations

1 site across 1 country: Netherlands