NCT02027532

Prevention of Infection in Closed Fractures: Cefazolin Versus Vancomycin

Prevention of Infection in Surgical Treatment of Closed Fractures: A Comparative Study of Cefazolin Versus Vancomycin

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 430 (actual)
• Sponsor: University of Tennessee · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the incidence rate of infection in surgical patients with closed fractures treated prophylactically with Cefazolin versus Vancomycin in the peri-operative period. The hypothesis of this study is that patients undergoing surgical treatment for closed fractures who are treated prophylactically with Vancomycin will have a lower incidence rate of infection than patients who are treated prophylactically with Cefazolin.

Conditions

• Infection
• Closed Fractures

Interventions

Type	Name	Description
DRUG	Cefazolin
DRUG	Vancomycin

Timeline

• Start date: 2009-10-01
• Primary completion: 2015-06-01
• Completion: 2017-12-01
• First posted: 2014-01-06
• Last updated: 2018-07-11

Locations

1 site across 1 country: United States