NCT02026492

Exercise Challenge in a Cold Chamber

Exercise-induced Bronchoconstriction in a Cold Chamber Compared to Methacholine Challenge

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 79 (actual)
• Sponsor: Johann Wolfgang Goethe University Hospital · Academic / Other
• Sex: All
• Age: 6 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the exercise-challenge in a cold chamber at 2-4°C to the gold standard the metacholine challenge in subjects showing symptoms of exercise-induced bronchoconstriction. The sensitivity and repeatability of the exercise test will be measured.

Detailed description

Subjects suffering form exercise-induced bronchoconstriction (EIB) usually have a normal lung function testing at rest. To provoke asthma symptoms a provocation test is necessary, e.g., by bronchial methacholine testing or by a standardised exercise test on a treadmill. The correlation between methacholine and exercise test is fair, possibly because both methods measure different kinds of bronchial hyperresponsiveness. Moreover, the sensitivity and the repeatability of the exercise test is fair. The value of the methacholine test to predict a positive exercise test will be measured. We hypothesize that the exercise test in a cold chamber, a combination of two provocation methods cold air and exercise, is more sensitive to detect EIB and that the test has a better repeatability.

Conditions

• Exercise-induced Asthma

Interventions

Type	Name	Description
OTHER	Exercise challenge in a cold chamber	Exercise challenge is defined as running on a treadmill for 6-8 minutes on submaximal work load in a cold chamber.
OTHER	Methacholine challenge	nebulized metacholine administered at following doses: 0,01mg, 0,1mg, 0,4mg, 0,8mg und 1,6mg
OTHER	Exercise challenge in room temperature	Exercise challenge is defined as running on a treadmill for 6-8 minutes on submaximal work load in room temperature.

Timeline

• Start date: 2013-06-01
• Primary completion: 2014-07-01
• Completion: 2014-07-01
• First posted: 2014-01-03
• Last updated: 2015-03-17

Locations

1 site across 1 country: Germany