NCT02024867

Evaluation of 3 Versus 10 Days of Antibiotics in Skin Abscesses After Surgical Drainage

Randomized Non-inferiority Trial of 3 Versus 10 Days of Trimethoprim-Sulfamethoxazole in Community-Associated Skin Abscesses After Surgical Drainage

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 249 (actual)
• Sponsor: Lucy Holmes, MD · Academic / Other
• Sex: All
• Age: 3 Months – 17 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to determine if there is a difference in treatment failures and recurrent skin infections when patients are given 3 or 10 days of antibiotics for uncomplicated skin abscesses after they have been surgically drained.

Detailed description

Patients age 3 months to 17 years presenting to a pediatric Emergency Department (ED) with an uncomplicated skin abscess that required surgical drainage were randomized to receive 3 or 10 days of oral trimethoprim-sulfamethoxazole. Patients were evaluated 10 to 14 days later to assess for cure. Patients were contacted 1 month later to determine if they had developed another skin infection. Outcomes were also stratified by methicillin-resistent staphylococcus aureus (MRSA) and methicillin-sensitive staphylococcus aureus (MSSA).

Conditions

• Skin Disease, Bacterial
• Abscess

Interventions

Type	Name	Description
DRUG	Trimethoprim-Sulfamethoxazole	3 versus 10 days of drug

Timeline

• Start date: 2010-02-01
• Primary completion: 2012-01-01
• Completion: 2012-07-01
• First posted: 2013-12-31
• Last updated: 2015-10-19
• Results posted: 2014-09-15

Locations

1 site across 1 country: United States