NCT02022176

Modulation of Metabolic Rate by Inorganic Nitrate

Dietary Inorganic Nitrate: Effects on Metabolic Rate, Reactive Oxygen Species Production, Glucose Uptake and Primary Myotube Respiration.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 55 (actual)
• Sponsor: Karolinska Institutet · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine the effects of sodium nitrate on resting metabolic rate, glucose uptake and formation of reactive oxygen species in humans.

Conditions

• Resting Metabolic Rate

Interventions

Type	Name	Description
OTHER	Glucose Uptake	Glucose uptake is measured by oral glucose tolerance test and euglycemic clamp
OTHER	Resting metabolic rate	Resting metabolic rate is measured by indirect calorimetry after an over-night fast
OTHER	Nitrite infusion	Sodium nitrite or saline was infused at escalating doses at a rate of 1, 10 or 100 nmol kg-1 min-1 (10 minutes per dose) in a randomized, double blinded cross-over fashion

Timeline

• Start date: 2008-03-01
• Primary completion: 2013-09-01
• Completion: 2013-09-01
• First posted: 2013-12-27
• Last updated: 2014-01-03

Locations

1 site across 1 country: Sweden