NCT02020395

Effect of a Test Meal on Satiation Hormones in Obese and Normal Weight Adolescents

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 11 Years – 16 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to examine ghrelin, amylin, glucagon and glucagon-like peptide (GLP)-1 responses to a test meal in lean and obese individuals.

Detailed description

The primary hypothesis is that obese adolescents have a disturbed balance of hormones associated with appetite regulation with less suppression of ghrelin and attenuated stimulation of GLP-1 secretion in response to meal intake compared to lean normal weight controls. A second aim of the study was to test which gastrointestinal peptides are most associated with insulin resistance.

Conditions

• Endocrine System Diseases

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	test meal (500 kcal)	whole wheat bread (68 g), butter(10 g), ham (25 g); chocolate cream (90 g); orange juice (200 mL)
DIETARY_SUPPLEMENT	test meal (500 kcal)	whole wheat bread (68 g), butter(10 g), ham (25 g); chocolate cream (90 g); orange juice (200 mL)

Timeline

• Start date: 2009-06-01
• Primary completion: 2009-12-01
• Completion: 2013-10-01
• First posted: 2013-12-24
• Last updated: 2013-12-24

Locations

1 site across 1 country: Switzerland