NCT02020187

Aerobic Training in Patients With Congenital Myopathies

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Congenital myopathies are clinical and genetic heterogeneous disorders characterized by skeletal muscle weakness. Most patients experience muscle weakness and fatigue throughout their life. However, progression of symptoms is rare. There are no specific treatments for congenital myopathies. Training has been shown to benefit several other muscle diseases with weakness, but the defect in congenital myopathies involves contractile proteins of the sarcomere, why the effect of training is uncertain in these conditions. The investigators will therefore investigate the effect cycle-ergometer training for 30 minutes, three times weakly, for ten weeks in 15 patients with congenital myopathy. Another 5-10 congenital myopathy patients, who do not train, will serve as controls for the trained patients. The study starts and ends with a test day, where efficacy based on VO2max, performance in functional tests and a questionnaire will be assessed.

Detailed description

10 weeks of cycle-ergometer training at home. Intensity at 70% of maximal VO2,max.

Conditions

• Congenital Myopathy

Interventions

Type	Name	Description
OTHER	Exercise on a cycle-ergometer	Home training on an ergometer-cycle 30 minutes every other day or at least three times a week. Subject will exercise in a pulse interval corresponding to 70% of their maximal VO2.

Timeline

• Start date: 2013-09-01
• Primary completion: 2014-11-01
• Completion: 2014-11-01
• First posted: 2013-12-24
• Last updated: 2015-05-12

Locations

1 site across 1 country: Denmark