NCT02019186

Effects of Vitamin C and E on Endothelial Function in Adolescent Diabetes

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: Nationwide Children's Hospital · Academic / Other
• Sex: All
• Age: 8 Years – 15 Years
• Healthy volunteers: Not accepted

Summary

The endothelium is the lining of the blood vessels that helps prevent damage to the vessels. The endothelium does not function as well as it should in adolescents with type 1 diabetes. This causes future diabetes complications. Adolescents with diabetes also have abnormalities of the cells that repair the endothelium. These abnormalities may be due to damage caused by intermittent hyperglycemia. This studied is designed to study whether low dose, combined Vitamin C and E supplementation improves endothelial function and repair in adolescents with type 1 diabetes.

Conditions

• Type 1 Diabetes Mellitus

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Vitamin C	\<30 kg 250 mg 30-60 kg 500 mg \>60 kg 750 mg
DIETARY_SUPPLEMENT	Vitamin E	\<30 kg 100 IU, 30-60 kg 200 IU, \>60 kg 300 IU

Timeline

• Start date: 2013-12-01
• Primary completion: 2015-01-01
• Completion: 2015-01-01
• First posted: 2013-12-24
• Last updated: 2015-02-03

Locations

1 site across 1 country: United States