NCT02018081

Pharmacokinetics of Levofloxacin in Intensive Care Unit

Population Pharmacokinetics of Levofloxacin in Intensive Care Patients With Severe Community-acquired Pneumonia.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: University Hospital, Toulouse · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is 1. to describe levofloxacin pharmacokinetics in ICU patients suffering from pneumonia with taking into account physio-pathological parameters. 2. to verify clinical and bacteriological efficiency and to know if the peak/Minimum Inhibitory Concentration (MIC) ratio \> 5 and Area Under Curve (AUC) /Minimum Inhibitory Concentration(MIC) ratio \> 125. No therapeutic drug monitoring will be performed in this study.

Conditions

• Intensive Care Unit Syndrome
• Community-acquired Pneumonia

Interventions

Type	Name	Description
DRUG	Levofloxacin	8 blood sampling by patients between the 48th and 60th

Timeline

• Start date: 2012-03-01
• Primary completion: 2014-09-01
• Completion: 2014-09-01
• First posted: 2013-12-23
• Last updated: 2015-03-05

Locations

1 site across 1 country: France