NCT02017119

Comparison Between Lactulose and Lactulose-Paraffin in Cirrhotic Patients

Comparison Between Lactulose and Lactulose-Paraffin in Cirrhotic Patients: Impact on the Recurrence of Encephalopathy, Tolerance and Adherence to Treatment, Costs, and Quality of Life

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Hepatic encephalopathy (HE) is an important complication of liver cirrhosis. Lactulose is a first line treatment for HE, but the adherence to this treatment is relatively low, due to side effects such as diarrhea, distention, etc.

Detailed description

Lactulose is a first line treatment for HE, but the adherence to this treatment is relatively low due to side effects. Lactulose-paraffin recently available in the market can be used for the treatment of HE, and possibly have fewer side effects. The aim of this study was to compare the adherence of the treatment of lactulose and lactulose-paraffin.

Conditions

• Cirrhosis
• Hepatic Encephalopathy

Interventions

Type	Name	Description
DRUG	Comparison between Lactulose and Lactulose-Paraffin

Timeline

• Start date: 2011-01-01
• Primary completion: 2014-05-01
• Completion: 2014-06-01
• First posted: 2013-12-20
• Last updated: 2014-08-20

Locations

1 site across 1 country: Mexico