Trials / Completed
CompletedNCT02016365
Safety and Efficacy Study of Doxycycline/UrsoDeoxyCholicAcid on Disease Progression in ATTR Amyloidosis
A Phase II Multicenter Pilot Study of the Safety and Efficacy of Doxycycline/UrsoDeoxyCholicAcid on Disease Progression in ATTR Amyloidosis
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 55 (actual)
- Sponsor
- Umeå University · Academic / Other
- Sex
- All
- Age
- 50 Years
- Healthy volunteers
- Not accepted
Summary
The primary objective for this study is to evaluate the efficacy of doxycycline + ursodeoxycholic acid (UDCA) on disease progression in Transthyretin Amyloidosis (ATTR) subjects with cardiomyopathy with or without neuropathy.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Doxycycline | 200 mg/day (100 mg twice daily, orally) for 4 weeks with a pause of 2 weeks in combination with UDCA |
| DRUG | Ursodeoxycholic acid | 750 mg/day (500 mg +250mg orally) continuously |
Timeline
- Start date
- 2012-02-01
- Primary completion
- 2014-12-01
- Completion
- 2014-12-01
- First posted
- 2013-12-20
- Last updated
- 2016-05-12
Locations
3 sites across 1 country: Sweden
Source: ClinicalTrials.gov record NCT02016365. Inclusion in this directory is not an endorsement.