NCT02013856

The Effects of Apple Derived Flavanols on Cardiovascular Disease Risk (FLAVASCULAR Study)

The Effects of Apple Derived Flavanols on Cardiovascular Disease Risk

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Quadram Institute Bioscience · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Accepted

Summary

Fruit and vegetable rich diets are associated with a reduced risk of cardiovascular disease (CVD). The protective effect may be ascribed to compounds contained within these foods, called flavonoids. Flavanols (epicatechin and procyanidins) are a particular group of flavonoids and are found mostly in apples, berry fruits, dark chocolate, tea and red wine. There is evidence to suggest that ingestion of flavanol rich foods and beverages beneficially alter 'markers' of CVD risk (e.g. blood pressure). The aim of this study is to determine the acute and chronic effects of apple derived flavanols on some risk markers for CVD.

Detailed description

This study is a single arm randomized, 4-phase crossover design.

Conditions

• Blood Pressure

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Low Epicatechin and procyanidin	70 mg epicatechin and 65 mg procyanidins once daily for 28 days
DIETARY_SUPPLEMENT	High Epicatechin and procyanidin	140 mg epicatechin and 130 mg procyanidins once daily for 28 days
DIETARY_SUPPLEMENT	High procyanidin	No epicatechin and 130 mg procyanidins once daily for 28 days
DIETARY_SUPPLEMENT	Placebo	Placebo control once daily for 28 days

Timeline

• Start date: 2014-07-01
• Primary completion: 2016-10-01
• Completion: 2016-10-01
• First posted: 2013-12-17
• Last updated: 2016-12-02

Locations

1 site across 1 country: United Kingdom