NCT02013076

Determinants Of Oral Corticosteroid Responsiveness in Wheezing Asthmatic Youth

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,011 (actual)
• Sponsor: St. Justine's Hospital · Academic / Other
• Sex: All
• Age: 1 Year – 17 Years
• Healthy volunteers: Not accepted

Summary

The aim of the prospective cohort study is to: (1) document the magnitude of response to oral corticosteroids administered to children presenting to the emergency department with moderate or severe asthma and (2) quantify clinically available potential determinants of the response to corticosteroids, such as age, gender, triggers of the index exacerbation, environmental tobacco smoke (ETS), gene polymorphisms, and their interactions.

Detailed description

The objective of the large multicentre cohort study is to quantify the response to oral corticosteroids in children aged 1 to 17 years presenting to the ED with a moderate or severe asthma exacerbation. The main outcome is hospital admission within 72 hours of the oral corticosteroid administration. Secondary outcomes include the change in Pediatric Respiratory Assessment Measure (PRAM), length of active treatment and other markers of response to therapy in the ED as well as markers of recovery over the next 10 days.

Conditions

• Asthma

Timeline

• Start date: 2011-01-01
• Primary completion: 2014-01-01
• Completion: 2014-01-01
• First posted: 2013-12-17
• Last updated: 2014-07-22

Locations

5 sites across 1 country: Canada