Trials / Terminated
TerminatedNCT02012153
Mesenchymal Stromal Cells in Kidney Transplant Recipients
Autologous Mesenchymal Stromal Cells to Induce Tolerance in Living-donor Kidney Transplant Recipients
- Status
- Terminated
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 3 (actual)
- Sponsor
- Mario Negri Institute for Pharmacological Research · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The general aim of the present study is to test a cell therapy with autologous ex-vivo expanded mesenchymal stromal cells (MSCs) as a strategy to induce tolerance in living-donor kidney transplant recipients. MSCs will be prepared accordingly to established protocols, starting from bone marrow explants of living-donor kidney transplant recipients obtained 3-4 months before kidney transplant. From these samples, MSCs will be expanded in Good Manufacturing Practice (GMP) approved facilities and used for the present study in patients undergoing kidney transplantation.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | Mesenchymal Stromal Cells |
Timeline
- Start date
- 2013-12-04
- Primary completion
- 2023-05-29
- Completion
- 2023-05-29
- First posted
- 2013-12-16
- Last updated
- 2023-06-01
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT02012153. Inclusion in this directory is not an endorsement.