NCT02011672

Effect of Milk Ingredients on Glucose Regulation and Inflammation

Effect of Milk Ingredients on Glucose Regulation and Inflammation in Overweight Subjects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: NIZO Food Research · Academic / Other
• Sex: Male
• Age: 50 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Background: Recent advances in science have established a fundamental role for low grade chronic inflammation in mediating all stages of most of the non-communicable diseases associated with ageing. Pro-inflammatory effects of hyperglycemia have been described. Dairy and its components are known to exert beneficial effects on postprandial hyperglycemia. This study investigates if dairy, normal and enriched, can reduce chronic inflammation via improvement in glucose regulation. Objective: To compare the effect of a nutrient-enriched dairy drink on parameters of glucose regulation and postprandial inflammation with the effect of a standard milk drink, within a population of overweight, apparently healthy subjects. Study design: The study is designed as a double-blind randomized placebo-controlled parallel trial during 7 weeks, during which the test and reference products will be consumed at home. Main study parameters/endpoints: The difference in absolute change in fasting blood plasma concentration of glucose, insulin and IL-6, from baseline to endpoint, and the difference in postprandial response of plasma concentration of glucose, insulin and IL-6 at the end of the treatment period, between subjects consuming the test and reference product.

Conditions

• Glucose Regulation
• Low-grade Inflammation

Interventions

Type	Name	Description
OTHER	nutrient-enriched milk
OTHER	regular milk

Timeline

• Start date: 2013-11-01
• Primary completion: 2014-04-01
• Completion: 2014-06-01
• First posted: 2013-12-13
• Last updated: 2014-09-09

Locations

1 site across 1 country: Netherlands