NCT02009787

Efficacy Study of Vitamin D and Statins to Treat Hypercholesterolemia

Effect of Vitamin D and Statins on Plasma Lipid Profiles in Chinese Patients With Hypercholesterolemia

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 56 (estimated)
• Sponsor: Shi Yang · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The investigators planned to research the effect of vitamin D supplementation as an adjuvant therapy for patients with hypercholesterolemia.

Detailed description

Vitamin D is primarily generated in the skin, in response to direct absorption of ultraviolet B radiation. Vitamin D can also be obtained through fortified foods and oral supplements. Lipid abnormalities are common in the general population, and are regarded as a modifiable risk factor for cardiovascular disease. Recently low vitamin D status has been shown to be associated with increased risk of developing hyperlipidemia. Statins are normally the first-line therapy for hypercholesterolemia. It is also reported that vitamin D can improve serum lipid levels. However, its effects on hypercholesterolemia patients remain unclear. The investigators planned to determine the efficacy of combination therapy with statins and vitamin D in a cohort of hypercholesterolemia patients. This study may shed light as to whether oral vitamin D supplementation can be an adjunct therapy in hypercholesterolemia patients.

Conditions

• Primary Hypercholesterolemia

Interventions

Type	Name	Description
DRUG	vitamin D3 tablets	2000 IU vitamin D3 tablets were taken daily for 6 months
DRUG	placebo tablets	2000 IU placebo tablets were taken daily for 6 months

Timeline

• Start date: 2013-12-01
• Primary completion: 2015-01-01
• Completion: 2015-01-01
• First posted: 2013-12-12
• Last updated: 2013-12-12

Locations

1 site across 1 country: China