NCT01999881

Impacts of Exercise on Prognostic Biomarkers in Lung Cancer Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: University of Wisconsin, Madison · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This randomized pilot clinical trial studies exercise intervention in improving quality of life and exercise capacity and reducing inflammation and oxidative stress in patients with lung cancer and their support persons. Exercise therapy may help improve quality of life, may increase exercise capacity, and may reduce inflammation and oxidative stress in patients with lung cancer and their supporters.

Detailed description

PRIMARY OBJECTIVES: I. Determine the effect of an eight-week exercise intervention on biomarkers of inflammation, oxidative stress, exercise capacity, and quality of life in lung cancer patients. SECONDARY OBJECTIVES: I. Determine the effect of an eight-week exercise intervention on markers of stress and quality of life in the support person of lung cancer patients. OUTLINE: Participants are randomized to 1 of 2 arms. ARM A: Patients and their support persons undergo a supervised combined aerobic exercise comprising walking, cycling, or video-based aerobics and strength training using resistance bands for 40 minutes 2 days a week at the University of Wisconsin Hospital and Clinic (UWHC) and 3 days a week at home over 8 weeks. ARM B: Patients and their support persons undergo the usual care over 8 weeks.

Conditions

• Extensive Stage Small Cell Lung Cancer
• Healthy, no Evidence of Disease
• Limited Stage Small Cell Lung Cancer
• Recurrent Non-small Cell Lung Cancer
• Recurrent Small Cell Lung Cancer
• Stage IA Non-small Cell Lung Cancer
• Stage IB Non-small Cell Lung Cancer
• Stage IIA Non-small Cell Lung Cancer
• Stage IIB Non-small Cell Lung Cancer
• Stage IIIA Non-small Cell Lung Cancer
• Stage IIIB Non-small Cell Lung Cancer
• Stage IV Non-small Cell Lung Cancer

Interventions

Type	Name	Description
BEHAVIORAL	exercise intervention	Receive aerobic and exercise intervention
PROCEDURE	standard follow-up care	Receive usual care
PROCEDURE	quality-of-life assessment	Ancillary studies
OTHER	laboratory biomarker analysis	Correlative studies

Timeline

• Start date: 2013-12-01
• Primary completion: 2015-07-01
• Completion: 2016-02-01
• First posted: 2013-12-03
• Last updated: 2019-11-18

Locations

2 sites across 1 country: United States