NCT01995448

Prognostic Interest of Leucocyte Immunophenotyping During the Acute Phase of Sepsis

Prognostic Interest of Leucocyte Immunophenotyping Using Multiparameter 8-color Flow Cytometry During the Acute Phase of Sepsis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,000 (actual)
• Sponsor: University Hospital, Limoges · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Septic shock is still a major cause of death in ICU. Sepsis diagnosis is linked with many clinical, hemodynamic and biological criteria which have a low sensitivity and specificity if they are considered separately. The extensive experimental data which have been published contrast with the hematological data collected by the physician at patient's bedside especially regarding neutrophils and platelets levels. When there is no obvious clinical sign, a biological tool reflecting the patient's immune status could be useful to understand the physiopathology of Sepsis and to predict the progression of the disease in the patient. On the long-term it could also help to define management strategies.

Conditions

• Sepsis With Acute Organ Dysfunction

Interventions

Type	Name	Description
BIOLOGICAL	Blood test	Residue of blood further to NFS.

Timeline

• Start date: 2013-11-01
• Primary completion: 2015-06-01
• Completion: 2015-06-01
• First posted: 2013-11-26
• Last updated: 2016-02-24

Locations

9 sites across 1 country: France