Trials / Terminated
TerminatedNCT01992861
MRI and PET Imaging in Predicting Treatment Response in Patients With Stage IB-IVA Cervical Cancer
MRI- and PET-Predictive-Assay of Treatment Outcome in Cancer of the Cervix
- Status
- Terminated
- Phase
- —
- Study type
- Observational
- Enrollment
- 51 (actual)
- Sponsor
- University of Washington · Academic / Other
- Sex
- Female
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This trial studies magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging in predictive treatment response in patients with stage IB-IVA cervical cancer. MRI is a procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body. PET is a procedure in which a small amount of radioactive glucose (sugar) is injected into a vein, and a scanner is used to make detailed, computerized pictures of areas inside the body where the glucose is taken up. Comparing results of diagnostic procedures, such as MRI and PET, done before, during and after radiation and chemotherapy may help doctors predict a patient's response to treatment and help plan the best treatment.
Detailed description
OUTLINE: Patients undergo radiation therapy and receive chemotherapy per standard of care. Patients undergo dynamic contrast-enhanced (DCE) MRI, diffusion-weighted (DW) MRI, and magnetic resonance (MR) spectroscopy at baseline, 2-2.5 weeks, 4-5 weeks, and 1 month following radiation therapy completion, and fludeoxyglucose F 18 (FDG) PET/computed tomography (CT) at baseline, 2-2.5 weeks, and 4-5 weeks. After completion of study, patients are followed up at least every 3-6 months for 5 years.
Conditions
- Cervical Adenocarcinoma
- Cervical Adenosquamous Carcinoma
- Cervical Squamous Cell Carcinoma, Not Otherwise Specified
- Cervical Undifferentiated Carcinoma
- Recurrent Cervical Carcinoma
- Stage IB2 Cervical Cancer
- Stage II Cervical Cancer
- Stage IIA Cervical Cancer
- Stage IIB Cervical Cancer
- Stage III Cervical Cancer
- Stage IIIA Cervical Cancer
- Stage IIIB Cervical Cancer
- Stage IVA Cervical Cancer
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Computed Tomography | Undergo FDG PET/CT |
| PROCEDURE | Diffusion Weighted Imaging | Undergo DW MRI |
| PROCEDURE | Dynamic Contrast-Enhanced Magnetic Resonance Imaging | Undergo DCE MRI |
| RADIATION | Fludeoxyglucose F-18 | Undergo FDG PET/CT |
| PROCEDURE | Magnetic Resonance Spectroscopic Imaging | Undergo MR spectroscopy |
| PROCEDURE | Positron Emission Tomography | Undergo FDG PET/CT |
Timeline
- Start date
- 2014-02-14
- Primary completion
- 2022-01-01
- Completion
- 2022-01-01
- First posted
- 2013-11-25
- Last updated
- 2023-06-26
Locations
6 sites across 3 countries: United States, Canada, Hong Kong
Source: ClinicalTrials.gov record NCT01992861. Inclusion in this directory is not an endorsement.