NCT01988402

Does Allopurinol Prolong a Treated, Acute Gout Flare?

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 35 (actual)
• Sponsor: 59th Medical Wing · Federal
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a double blind placebo controlled study to determine whether starting allopurinol during a treated acute gout attack will have any effect on the duration of the attack.

Detailed description

Traditional teaching holds that starting allopurinol during an acute gout attack will prolong the attack. Recent expert opinion from the American College of Rheumatology Guidelines is that allopurinol may be started during an acute, treated gout attack. This study is designed to test the hypothesis that allopurinol does not prolong an acute, treated gout attack. Patients will either take allopurinol capsules or and identical capsule containing no allopurinol (placebo) over 28 days, starting within 72 hours of a gout attack that is being treated with other standard measures. During the study, neither the patient nor the examiner will know what pills are being taken. The time to resolution of the attack is the primary outcome measure. Pain level, serum uric acid level, and complications of therapy will also be monitored. A minimum of 32 patients completing the study are needed for a meaningful conclusion.

Conditions

• Gout

Interventions

Type	Name	Description
DRUG	allopurinol
DRUG	Placebo (sugar pill)

Timeline

• Start date: 2007-12-01
• Primary completion: 2013-06-01
• Completion: 2013-06-01
• First posted: 2013-11-20
• Last updated: 2018-02-14
• Results posted: 2015-01-05

Locations

1 site across 1 country: United States