NCT01988389

Effect of Apples on cardioVascular Risk And Gut Health

Effect of Apples Consumption on Blood Lipid Levels,Vascular Function and Gut Health in Moderate Hypercholesterolemic Subjects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: University of Reading · Academic / Other
• Sex: All
• Age: 23 Years – 69 Years
• Healthy volunteers: Accepted

Summary

There is now considerable scientific evidence that a diet rich in fruits and vegetables could improve human health. Apples are among the most frequently consumed fruits in the world. Epidemiological studies have linked frequent apple consumption with several health benefits including a reduced risk of cardiovascular disease. Apples are an important source of polyphenols and fiber and their beneficial effects could be attributed to this content; however, their impact on our health is not clear. Although, there are some studies that have reported cholesterol lowering effects the results are inconsistent. Furthermore, few studies have explored the impact on vascular function and gut microbiota. The objective of the current study is to assess whether a regular apple consumption, reduces total cholesterol levels, improves vascular function and gut microbiota profile in mildly hypercholesterolemic subjects compared with a control, sugar matched commercial clear apple juice squash.

Conditions

• Mild Hypercholesterolemia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	whole apples (WA)
DIETARY_SUPPLEMENT	apple juice (AJ)

Timeline

• Start date: 2013-09-01
• Primary completion: 2014-10-01
• Completion: 2014-11-01
• First posted: 2013-11-20
• Last updated: 2015-03-09

Locations

1 site across 1 country: United Kingdom