NCT01988298

Nonsteroidal Antiinflammatory Drugs in Women With Postpartum Pre-eclampsia

Ibuprofen Versus Acetaminophen in Women With Severe Pre-eclampsia After Vaginal Delivery.

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 114 (actual)
• Sponsor: Complejo Hospitalario Dr. Arnulfo Arias Madrid · Academic / Other
• Sex: Female
• Age: 15 Years – 44 Years
• Healthy volunteers: Accepted

Summary

Hypertensive disorders of pregnancy are a major cause of maternal mortality and morbidity, especially in developing countries. Postpartum hypertension can be related to persistence of gestational hypertension, preeclampsia, or preexisting chronic hypertension, or it could develop de novo secondary to other causes. The available data in the medical literature have primarily focused on antenatal and peripartum management. There are few data regarding the evaluation in women who are diagnosis with postpartum hypertension. Some medications that cause vasoconstriction are often used for pain relief, in women having perineal lacerations, episiotomy, or cesarean delivery. Such women usually require large doses of nonsteroidal antiinflammatory drugs that are associated with vasoconstriction and sodium and water retention, this drugs can result in severe hypertension. The purpose of this study is to evaluate maternal postpartum hypertension in women with severe preeclampsia treated with nonsteroidal antiinflammatory drugs or acetaminophen.

Detailed description

Our objective is evaluate Ibuprofen or acetaminophen used for pain during the postpartum period in women with severe pre-eclampsia. We include only women with vaginal delivery.

Conditions

• Hypertension

Interventions

Type	Name	Description
DRUG	Ibuprofen	Ibuprofen 400 mg each 8 hours
DRUG	Acetaminophen	Control group

Timeline

• Start date: 2013-10-01
• Primary completion: 2015-02-01
• Completion: 2015-02-01
• First posted: 2013-11-20
• Last updated: 2015-07-28

Locations

1 site across 1 country: Panama