NCT01984944

Characterisation of Circadian Rhythm in Autistic Spectrum Disorder

Characterisation of Circadian Rhythm in Autistic Spectrum Disorder : a Clinical, Biochemical and Genetic Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 6 Years
• Healthy volunteers: Accepted

Summary

Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions characterized by deficits in social communication, delay in language and repetitive behaviors. Results from genetic studies reveal one pathway associated with susceptibility to ASDs, which includes synaptic cell adhesion molecules. Among the factors that could modulate this pathway are the genes controlling circadian rhythms. Sleep disorders and low melatonin levels are frequently observed in ASDs. Thus investigator will characterize the circadian rhythms of patients with ASD and search for circadian rhythms genes polymorphisms.

Conditions

• Autistic Disorder

Interventions

Type	Name	Description
OTHER	Autistic functional exploration	* 50 adults with urinary sample, core body temperature rhythm, Circadian rhythms assessed with actometer * 25 childs with urinary sample, Circadian rhythms assessed with actometer
OTHER	Control functional exploration	* 50 adults with urinary sample, core body temperature rhythm, Circadian rhythms assessed with actometer * 25 childs with urinary sample, Circadian rhythms assessed with actometer

Timeline

• Start date: 2009-10-01
• Primary completion: 2013-08-01
• Completion: 2013-08-01
• First posted: 2013-11-15
• Last updated: 2014-11-07

Locations

1 site across 1 country: France