NCT01983826

Dietary Nitrates and Vascular Function in Patients With Peripheral Artery Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: University of Iowa · Academic / Other
• Sex: All
• Age: 50 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The overarching question addressed in the current project is: Does dietary nitrate supplementation (8 weeks) improve physiological function in patients with peripheral arterial disease (PAD)? The investigators will specifically address whether dietary nitrate supplementation enhances blood vessel function, blood pressure regulation, and exercise capacity. The proposed project uses an array of clearly defined measurements which will allow investigators to quantify blood vessel function (vasodilator responsiveness and arterial stiffness), blood pressure (variability and responsiveness to stress), and functional capacity before and after 8 weeks of dietary supplementation.

Conditions

• Peripheral Artery Disease

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Sodium Nitrate	Sodium Nitrate (1g/day) for 8 weeks
OTHER	Placebo	Microcrystalline cellulose (daily) for 8 weeks

Timeline

• Start date: 2013-11-01
• Primary completion: 2016-06-30
• Completion: 2016-06-30
• First posted: 2013-11-14
• Last updated: 2019-06-03
• Results posted: 2019-06-03

Locations

1 site across 1 country: United States