NCT01982734

Improved Oral Bioavailability of Curcumin Incorporated Into Micelles

Novel Strategies for the Enhancement of the Potency of Nutraceuticals With Low Oral Bioavailability and Their Application in Novel Functional Foods for Optimum Protection of the Aging Brain

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: University of Hohenheim · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Curcumin, a lipophilic polyphenol derived from the plant curcuma longa possesses numerous health-promoting activities. The oral bioavailability of curcumin is low due to its poor aqueous solubility, limited gastrointestinal absorption, rapid metabolism and excretion. Therefore, we tested, in a randomized crossover study, simultaneous application of phytochemicals and micellar solubilisation, alone and together, as strategies to enhance the absorption of curcumin into the body. Furthermore, we investigated age and sex differences in curcumin pharmacokinetics.

Conditions

• Pharmacokinetics of New Curcumin Formulations
• Safety of New Curcumin Formulations

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	curcumin	80 mg curcumin were given orally either as native powder, native powder plus phytochemicals,micelles or micelles plus phytochemicals

Timeline

• Start date: 2012-11-01
• Primary completion: 2013-04-01
• Completion: 2013-04-01
• First posted: 2013-11-13
• Last updated: 2016-10-25

Locations

1 site across 1 country: Germany