NCT01981330

Pilot Study of Stem Cell Treatment of Patients With Vocal Fold Scarring

Pilot Study of Patients With Severe Hoarseness and Vocal Fold Scarring Treated With Mesenchymal Stem Cells With and Without Hyaluronan Gel

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Karolinska University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a pilot-study of 16 selected Swedish patients which all have severe hoarseness or aphonia due to vocal fold scarring (from previous surgery, radiation therapy, inflammation or possibly hereditary). The patients are operated with phonomicrosurgical dissection of the scarred vocal folds, removal or scar tissue and injection of autologous mesenchymal stroma cells, aMSC (which were previously harvested from each patients´s bone marrow, purified, expanded and characterized according to standard procedure at the Center of Hematology and Regenerative Medicine Karolinska University Hospital Huddinge). 8 Patients is planned to be treated with a single injection of aMSC and 8 patients with injection of aMSC mixed with a carrier hyaluronan gel developed at Uppsala University Sweden and at the Karolinska Institute. The laryngeal status, vocal fold function, and voice function will be followed individually with an advanced battery of examinations performed before and up to 1 year postoperatively. Side effects and complications are noted and reported during surgery and following surgery at regular intervals during at least 1 year Since spring 2015 no new patients have been recruited and no treatments are given during 2016 or 2017. The monitoring authority was changed from Swedish National Board of Health to Swedish Medical Product Agency (MPA) in March/April 2016. Further inclusions and treatments are postponed until permission is granted from MPA to continue the study.

Conditions

• Improved Healing of Scarred Vocal Folds
• Improved Vocal Fold Status
• Improved Vocal Fold Function

Interventions

Type	Name	Description
BIOLOGICAL	aMSC	aMSC injected into the vocal fold of the patient
BIOLOGICAL	aMSC+hyaluronan gel	aMSC+ hyaluronan gel is injected into the patients vocal fold

Timeline

• Start date: 2012-01-01
• Primary completion: 2020-02-24
• Completion: 2020-02-24
• First posted: 2013-11-11
• Last updated: 2020-02-25

Locations

1 site across 1 country: Sweden