NCT01979666

Nitrate Patch Use as Treatment of Knee AVN

the Effect of a Nitrate Patch on the Healing Process of AVN of the Knee

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Sheba Medical Center · Other Government
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The pathogenesis of AVN includes a defective blood supply to the knee joint. Local nitrates induce peripheral vasodilation and may improve blood supply to the affected tissue. This study aims to test whether the use of a nicotine patch may accelerate the healing process from AVN of the knee.

Detailed description

The main purpose of this study is to examine whether treatment with a local nitrate patch will improve MRI findings and clinical outcomes in patients with AVN of the knee. This is a double-blind prospective study that will include 50 adult volunteers, randomly assigned to a "nitrate" group that will be given a nitrate patch, and a "placebo" group that will be given a placebo patch. The following outcomes will be measured: * MRI findings before and after the patch treatment * Use of analgesics * Subjective pain relief.

Conditions

• Necrosis, Avascular, of Bone

Interventions

Type	Name	Description
DRUG	nitrate patch	patients in the study group will get a nitrate patch
DRUG	placebo patch	control group patients will get a placebo patch
DEVICE	MRI scan	MRI scan after 6 weeks of treatment

Timeline

• Start date: 2014-01-01
• Primary completion: 2019-01-01
• Completion: 2019-01-01
• First posted: 2013-11-08
• Last updated: 2024-04-02

Locations

1 site across 1 country: Israel