NCT01978132

Primary Hyperaldosteronism and Ischemia-reperfusion Injury

Primary Hyperaldosteronism and Endothelial Ischemia-reperfusion Injury

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Patients with primary hyperaldosteronism experience more cardiovascular events compared to patients with primary hypertension, independent of the blood pressure level. In this research we hypothesize that patients with primary hyperaldosteronism are more susceptible to ischemia-reperfusion injury.

Detailed description

Patients with PHA have an increased risk of cardiovascular events, independent of blood pressure level. Also in patients suffering a myocardial infarction, circulating aldosterone levels are associated with increased mortality. In animal models of myocardial infarction, the administration of exogenous aldosterone increased infarct size, although other studies did not report this effect. In similar models, antagonists of the mineralocorticoid receptor (MR) reduced infarct size, which was completely abolished in ecto-5'-nucleotidase (CD73, the enzyme that catalyses extracellular formation of the endogenous nucleoside adenosine) and adenosine receptor knock-out mice. Therefore, we hypothesize that patients with PHA have an increased susceptibility for ischemia-reperfusion (IR)-injury due to down-regulation of the enzyme CD73. We will use the reduction in brachial flow-mediated dilation (FMD) by forearm IR as a well-validated endpoint for (endothelial) IR-injury.

Conditions

• Primary Hyperaldosteronism

Interventions

Type	Name	Description
PROCEDURE	forearm ischemia and reperfusion	both arms will be subjected to 20 minutes of forearm ischemia and 20 minutes of reperfusion.

Timeline

• Start date: 2013-11-01
• Primary completion: 2017-05-01
• Completion: 2017-07-01
• First posted: 2013-11-07
• Last updated: 2017-10-12

Locations

1 site across 1 country: Netherlands