NCT01974700

Seizure Prophylaxis in Aneurysm Repair

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: Indiana University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Seizures are a potential complication of surgical repair of intracranial aneurysms. In order to prevent seizures, many surgeons administer prophylactic anti-epileptic medication during the intra-operative and post-operative period, however, such practice is not supported by clinical data. Retrospective review found the incidence of postoperative seizures was higher in those who received anti-epileptics versus those who did not. The goal is to examine the utility of levetiracetam (Keppra) for seizure prophylaxis in patients undergoing surgical repair of unruptured intracranial aneurysms.

Conditions

• Intracranial Aneurysms
• Seizures

Interventions

Type	Name	Description
DRUG	Levetiracetam	500 mg intravenous dose during the operative case then 500 mg orally twice a day for a total of seven days

Timeline

• Start date: 2013-07-01
• Primary completion: 2016-02-01
• Completion: 2016-02-01
• First posted: 2013-11-01
• Last updated: 2016-03-11
• Results posted: 2016-03-11

Locations

1 site across 1 country: United States