Trials / Completed
CompletedNCT01974024
Dexamethasone-induced Hiccup in Chemotherapy Patients Treated by Methylprednisolone Rotation
Antiemetic Corticosteroid Rotation From Dexamethasone to Methylprednisolone to Prevent Dexamethasone-Induced Hiccup in Cancer Patients Treated With Chemotherapy: A Randomized, Single-Blind, Crossover Phase III Trial
- Status
- Completed
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 65 (actual)
- Sponsor
- Chung-Ang University · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The aims of this study were to investigate the feasibility of methylprednisolone rotation as treatment of DIH.
Detailed description
we planned a randomized prospective trial for cancer patients with DIH. The objective of the present study was to determine whether the rotation of corticosteroids affects the incidence and intensity of DIH without compromising the antiemetic efficacy.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | methylprednisolone | Adult patients who experienced DIH within 3 days after the administration of dexamethasone as an antiemetic were screened. Eligible patients were randomly assigned to receive dexamethasone or methylprednisolone as an antiemetic (randomization phase). In the next cycle of chemotherapy, the dexamethasone group received methylprednisolone and vice versa in the methylprednisolone group (crossover phase). |
Timeline
- Start date
- 2013-10-01
- Primary completion
- 2016-06-30
- Completion
- 2016-07-31
- First posted
- 2013-11-01
- Last updated
- 2017-04-28
Locations
2 sites across 1 country: South Korea
Source: ClinicalTrials.gov record NCT01974024. Inclusion in this directory is not an endorsement.