NCT01973075

Genetic Etiology in Premature Ovarian Insufficiency

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: BEGUM AYDOGAN · Academic / Other
• Sex: Female
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Premature Ovarian Insufficiency (POI), first described by Albright in 1942, is defined as an increase in Follicle Stimulating Hormone (FSH), an insufficiency of the ovarian function leading to an early menopause (\<40 years of age).Today, only 35% of POI's etiology can be explained. Causes enlightening POI may be enumerated as follows, according to their frequency: genetic mutations, autoimmune defects and abnormalities detected on the X chromosome.The purpose of the study is to determine the frequency of the genetic abnormalities and polymorphisms described above in the POI Turkish population

Conditions

• Primary Ovarian Insufficiency
• Genetic Predisposition to Disease

Timeline

• Start date: 2013-11-01
• Primary completion: 2016-04-01
• Completion: 2017-04-01
• First posted: 2013-10-31
• Last updated: 2017-08-11

Locations

1 site across 1 country: Turkey (Türkiye)