NCT01971710

Advancing Community Level Action for Improving MCH/PMTCT

Advancing Community Level Action for Improving MCH/PMTCT (ACCLAIM): A Multi-Country Randomized Trial to Evaluate the Effectiveness of Selected Community-Level Interventions on Key MCH/PMTCT Outcomes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 187,335 (actual)
• Sponsor: Elizabeth Glaser Pediatric AIDS Foundation · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Accepted

Summary

The goal of the ACCLAIM (Advancing Community-Level Action for Improving MCH/PMTCT) project is to increase community demand for, uptake of, and retention in Maternal and Child Health (MCH) and/Prevention of Mother-to-child transmission of HIV (PMTCT) services to improve country progress toward elimination of pediatric HIV/AIDS.

Detailed description

This study will undertake a three-arm randomized trial in Swaziland, Uganda and Zimbabwe. Districts/regions (n=9) with 45 PMTCT-implementing health facilities and their catchment areas (populations 7300-27500), will be randomly allocated to three intervention arms: 1) community leader engagement, 2) community leader engagement with community days, or 3) community leader engagement with community days and male and female community peer groups. The primary study outcome is HIV exposed infants (HEI) returning to the health facility within two months for early infant diagnosis (EID) of HIV. Secondary study outcomes include: gestational age of women attending for first antenatal care, male partners tested for HIV, and HEI receiving nevirapine prophylaxis at birth. Changes in community knowledge, attitudes, practices and beliefs on MCH/PMTCT will be assessed through household surveys.

Conditions

• HIV

Interventions

Type	Name	Description
BEHAVIORAL	Community leader engagement	Community leaders conducting advocacy, community dialogue and community action plans on PMTCT/MCH
BEHAVIORAL	Community days	The provision of facilitated dialogues, advocacy and education, and selected health services, to a community on a specific day
BEHAVIORAL	Community Peer Groups	Pregnant women in community peer groups receiving information and education on PMTCT/MCH through 4 weekly peer-led classes . Men in community peer groups receiving information and education on their role in supporting women and families through 4 peer-led education sessions.

Timeline

• Start date: 2013-04-01
• Primary completion: 2015-12-01
• Completion: 2016-04-01
• First posted: 2013-10-29
• Last updated: 2021-02-08

Locations

3 sites across 3 countries: Eswatini, Uganda, Zimbabwe