NCT01963416

Effects of Fruit Consumption on Risk Factors of Chronic Disease

A Randomized Controlled, Crossover in Design, Double Blind Clinical Trial Investigating the Effects of Whole Versus Processed Fruit Consumption on Risk Factors for Chronic Disease and Performance Indicators.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 34 (actual)
• Sponsor: University of Reading · Academic / Other
• Sex: Male
• Age: 30 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Acute, randomized, placebo controlled, double blind, postprandial crossover study in male subjects. 4 intervention arms consisting of control, orange juice, whole orange, and processed whole orange to determine the effect of the interventions on the primary measure of flow mediated dilatation (FMD) and additional biomarkers of health. The study will also identify and quantify the main micronutrients and phytochemicals in each of the products and will identify and quantify the main micronutrients and phytochemicals and their metabolites in the subjects' plasma and/or urine. A subset of the study population (n=24) will be invited to participate in an additional arm of the main study which is summarised below.

Conditions

• Vascular Stiffness

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	macro- and micro-nutrient matched control (240 ml)
DIETARY_SUPPLEMENT	Orange juice
DIETARY_SUPPLEMENT	whole orange fruit
DIETARY_SUPPLEMENT	Processed whole orange

Timeline

• Start date: 2012-06-01
• Primary completion: 2012-12-01
• Completion: 2012-12-01
• First posted: 2013-10-16
• Last updated: 2013-10-16

Locations

1 site across 1 country: United Kingdom