NCT01962285

Neuronal Inertia in Propofol Anesthesia

Neuronal Inertia´s Effect on Pharmacological Behavior Representation of Propofol

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: Universidad del Desarrollo · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Loss and recovery of consciousness during propofol anesthesia seem to be mediated by different mechanisms beyond the actual effect-site concentration of anesthetic drug. This eventual difference between dose response curves for loss of consciousness (LOC) and for recovery of consciousness (ROC) beyond hysteresis has received the name of neuronal inertia. We performed a volunteer-study comparing LOC and ROC curves during a slow, steady-sate, stepped target controlled infusion of Propofol. Our hypothesis is that, at steady-state conditions between plasma an effect-site concentration, there is still going to exist a difference between LOC and ROC, demonstrating the existence of neuronal inertia.

Detailed description

Loss and recovery of consciousness during propofol anesthesia seem to be mediated by different mechanisms beyond the actual effect-site concentration of anesthetic drug. This eventual difference between dose response curves for loss of consciousness (LOC) and for recovery of consciousness (ROC) beyond hysteresis has received the name of neuronal inertia. We performed a volunteer-study comparing LOC and ROC curves, during a slow, steady-sate, stepped target controlled infusion of Propofol using Schnider's pharmacologic model. Our hypothesis is that, at steady-state conditions between plasma an effect-site concentration, there is still going to exist a difference between LOC and ROC, demonstrating the existence of neuronal inertia.

Conditions

• General Anesthesia
• Propofol Pharmacodynamics
• Propofol Target Controlled Infusion
• Loss of Consciousness and Recovery of Consciousness
• Propofol Plasma Concentration

Interventions

Type	Name	Description
DRUG	propofol targel controlled infusion	slow stepped propofol target controlled infusion using Schinider´s pharmacokinetic parameters seriated venous blood sampling

Timeline

• Start date: 2013-08-01
• Primary completion: 2013-09-01
• Completion: 2013-10-01
• First posted: 2013-10-14
• Last updated: 2013-10-14

Locations

1 site across 1 country: Chile