NCT01961206

Community-Onset Bacteremia Due to ESBL Producing E.Coli or K.Pneumoniae in China: Prevalence, Risk Factors and Prognosis

Community-Onset Bacteremia Due to Extended-Spectrum β-Lactamase (ESBL)Producing Escherichia Coli or Klebsiella Pneumoniae in China: Prevalence, Risk Factors and Prognosis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 960 (actual)
• Sponsor: Jian-cang Zhou M.D. · Academic / Other
• Sex: All
• Age: 18 Years – 95 Years
• Healthy volunteers: Not accepted

Summary

Escherichia coli is the leading cause of community-onset gram-negative bloodstream infections. There has been a dramatic increase in the prevalence of extended-spectrum b-lactamases producing E. coli and K.pneumoniae in the community, which was considered to be exclusively a nosocomial pathogen in recent years. As a result, the treatment options for community-onset infections due to ESBL-producing E. coli or K.pneumoniae are limited and the initial empirical therapy is often ineffective and associated with increased mortality. Although there were some reports of the risk factors of community-onset ESBL producing E. coli in Spain, Korea, and Canada, few empirical data were available about China. Therefore, the investigators aim was to investigate the epidemiology, risk factors, and the hospital outcomes for patients with community-onset bacteremia caused by ESBL producing E. coli or K.pneumoniae in China.

Detailed description

Eligibility criteria: 1. Inclusion criteria:Blood cultures demonstrated E.coli or K.pneumoniae among nonhospitalized patients or within 48 h after hospitalization. 2. Exclusion criteria:Patients with hospitalization in the past 1 month. Outcome measures: 1. Risk factors for community-onset bacteremia due to ESBL producing E. coli or K.pneumoniae 2. Microbial and clinical efficacy of commonly used antibiotics for community-onset bacteremia due to ESBL producing E. coli or K.pneumoniae

Conditions

• Community Acquired Infection

Interventions

Type	Name	Description
OTHER	bacteremia caused by ESBL producing E.coli or K.pneumoniae	community-onset bacteremia caused by ESBL producing E.coli or K.pneumoniae

Timeline

• Start date: 2013-10-01
• Primary completion: 2014-11-01
• Completion: 2015-09-01
• First posted: 2013-10-11
• Last updated: 2015-11-23

Locations

1 site across 1 country: China