NCT01956747

Optimization of Systemic Treatment Strategies in Elderly Patients With Advanced Solid Malignancies

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: Amsterdam UMC, location VUmc · Academic / Other
• Sex: All
• Age: 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to assess whether the presence of a Myelodysplastic Syndrome (MDS) , Idiopathic Cytopenia of Undetermined Significance (ICUS) or Idiopathic Dysplasia of Undetermined Significance (IDUS), correlates with treatment intensity and clinical outcome in older patients with advanced malignancies receiving palliative chemotherapy. We will study the relation between sarcopenia, comprehensive geriatric assessment en pharmacokinetics with treatment related toxicity as well. We hypothesize that a standardized flow cytometry test to determine bone marrow capacity, a Comprehensive Geriatric Assessment and/or measurement of human body composition with computerized tomography will provide an accurate tool to optimize treatment strategies in elderly patients with advanced malignancies.

Conditions

• Colorectum Advanced Malignancies
• Breast Advanced Malignancies
• Prostate Advanced Malignancies

Interventions

Type	Name	Description
PROCEDURE	venapunction
PROCEDURE	bone marrow punction

Timeline

• Start date: 2013-07-01
• Primary completion: 2019-12-01
• Completion: 2019-12-01
• First posted: 2013-10-08
• Last updated: 2020-11-20

Locations

1 site across 1 country: Netherlands