NCT01953393

The Acute Effects of Low-dose TNF-α on Glucose Metabolism and β-cell Function in Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: —
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: Male
• Age: 20 Years – 35 Years
• Healthy volunteers: Accepted

Summary

Type 2 diabetes is characterized by increased insulin resistance and impaired insulin secretion. In addition, type 2 diabetes is associated with low grade inflammation indicated by increased levels of proinflammatory cytokines such as TNF-α. TNF-α has previously been shown to impair peripheral insulin signaling in vitro and in vivo. However, it is unclear whether TNF-α may also affect endogenous glucose production (EGP) during fasting and glucose stimulated insulin secretion (GSIS) in vivo. We hypothesized that low dose TNF-α would increase EGP and attenuate GSIS. Recombinant human TNF-α or placebo was infused in healthy, non-obese and non-diabetic young men (n=10) during a 4-hour basal period followed by an intravenous glucose tolerance test (IVGTT).

Conditions

• Diabetes Type 2

Interventions

Type	Name	Description
OTHER	Low-dose TNF-alpha

Timeline

• Start date: 2006-04-01
• Primary completion: 2006-05-01
• Completion: 2006-10-01
• First posted: 2013-10-01
• Last updated: 2013-10-01

Locations

1 site across 1 country: Denmark