NCT01951963

Sub-dissociative Ketamine for the Management of Acute Pediatric Pain

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 77 (actual)
• Sponsor: HealthPartners Institute · Academic / Other
• Sex: All
• Age: 3 Years – 17 Years
• Healthy volunteers: Not accepted

Summary

The proposed trial is a prospective, double blinded, randomized control trial with the primary aim of determining whether a single, sub-dissociative dose of ketamine will decrease the total narcotic requirements of pediatric patients requiring intravenous analgesia in an urban emergency department (ED) compared to a group of patients who receive morphine alone for pain management. Patients are randomized to receive either a single bolus of ketamine (0.3 mg/kg) or a single bolus of morphine (0.05mg/kg). All subsequent pain management will be accomplished using morphine. Patient, family member, and research staff pain scores will be recorded, until 3 hours post study medication administration. Family members are contacted via telephone 24 hours post-ED discharge, and again at 7 days post-hospital discharge, for evaluation via Post Hospitalization Behavior Questionnaire. Narcotic equivalents will be calculated for up to 3 hours post study medication administration and compared between the ketamine and morphine groups.

Conditions

• Pain

Interventions

Type	Name	Description
DRUG	Ketamine
DRUG	Morphine

Timeline

• Start date: 2012-12-01
• Primary completion: 2015-06-01
• Completion: 2015-06-01
• First posted: 2013-09-27
• Last updated: 2018-07-03
• Results posted: 2017-10-16

Locations

1 site across 1 country: United States