NCT01950078

The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,533 (actual)
• Sponsor: Xianwei Zhang · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Objective: This study was conducted to explore the possible correlation between some gene related to pain sensation and individual basal pain perception and postoperative pain intensity in the general population. Methods: Patients receiving elective surgery under general anesthesia were recruited into this study. The investigators measured their preoperative pressure pain threshold (PPT) and pressure pain tolerance (PTO). Pain intensity at rest and movement after the operation was evaluated . And the PCA drug consumption were recorded. Also there were healthy college students volunteer be recruited into this study. The investigators measured their experimental pain sensitivity including pressure pain threshold (PPT) and pressure pain tolerance (PTO), etc. Then genotyping was carried out.

Detailed description

Subjects with the following diseases were excluded: known history of chronic disease, psychiatric diseases or communication disorders, diabetes mellitus, severe cardiovascular diseases, kidney or liver diseases with poor hepatic function, alcohol or drug abuse, heavy smoker, Pregnancy or at lactation period .

Conditions

• Pain
• Surgery

Timeline

• Start date: 2013-08-01
• Primary completion: 2014-08-01
• Completion: 2014-12-01
• First posted: 2013-09-25
• Last updated: 2015-02-23
• Results posted: 2015-02-23

Locations

1 site across 1 country: China